Protein Details: Small conductance calcium-activated potassium channel protein
Protein ID
ICDB_Pro_1147
Protein Name
Small conductance calcium-activated potassium channel protein
Gene Name
SK; CG10706
Organism
Drosophila melanogaster (Fruit fly)
Length
927 amino acids
AlphaFoldDB
AF-Q7KVW5-F1-model_v4.pdb
Function
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)
Sequence
MSIQKLNDTTNSGYVSSEETDSLLVSSSNPSKGGGRTALLRQVKSNSTNGPTTGASTSSSGSVSGGGGGSGSGGGSASGSAAGASKPTLMRQDRTSTYLTSPQQSQHARMGSEESMRGGASGAAGHDEDVEQGLVRSSIVPDIEVHEEDQEQHSQQLNATTMATMTNNQQQQQPTISIMNLSLKPGDSHSHSSSPGSHPNLGTSSYQNLASSIPPSVPSRCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQQQLQQQYHLQQQQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQSSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGGMRPFKQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYEMYMEERALTGGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHANLLNSMWLTAITFLCVGYGDIVPNTYCGRGITLTCGMVGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSS
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1261/rna.254306
RefSeq
NP_001096885.2 [Q7KVW5-6]; NP_525078.3 [Q7KVW5-4]; NP_726986.3 [Q7KVW5-1]; NP_726987.2 [Q7KVW5-7]; NP_726988.3 [Q7KVW5-2]; NP_726989.3 [Q7KVW5-8]; NP_996354.2 [Q7KVW5-5]